Human TOSO (C-TERMINAL) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human TOSO (C-TERMINAL) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse (expected from sequence), rat (expected from sequence) |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | IgG concentration 0.5 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This item detects an epitope within the C-terminal (CT) region of human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation.. Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS PAGE. MBS221472 detects an epitope within the C-terminal (CT) region of human Toso, also k |
| Immunogen | Immunogen: A 13 amino acid peptide from near the carboxy terminus of human Toso. Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antisera to human Toso were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human |
| Other Names | [fas apoptotic inhibitory molecule 3 isoform b; Fas apoptotic inhibitory molecule 3; fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso; Fas apoptotic inhibitory molecule 3; Regulator of Fas-induced apoptosis Toso], [FAIM3; FAIM3; FCMR; TOSO; TOSO] |
| Gene, Accession # | [TOSO], Gene ID: 9214, NCBI: NP_001135945.1, UniProt: O60667 |
| Catalog # | MBS221472 |
| Price | $375 |
| Order / More Info | Human TOSO (C-TERMINAL) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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