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Antigenic Specificity | Human Mothers against decapentaplegic homolog 3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | caprylic acid ammonium sulfate precipitate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and |
Immunogen | Immunogen: Recombinant human Mothers against decapentaplegic homolog 3 protein |
Other Names | [JV15-2 SMAD family member 3 SMAD3 MADH3] |
Gene, Accession # | Gene ID: 4088, NCBI: NP_001138574.1, UniProt: P84022 |
Catalog # | MBS7000752 |
Price | $160, $235 |
Order / More Info | Human Mothers against decapentaplegic homolog 3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |