DR3 / Apo3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DR3 / Apo3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.03 mg, 0.1 mg |
| Concentration | 0.5 mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background: Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily thromugh interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis thromugh TRADD, FADD, and caspase-8. DR3 is highly expressed in th |
| Immunogen | Immunogen: Synthetic peptide corresponding to residues surrounding amino acids 378 of mouse DR3 |
| Other Names | [WAL-1; APO-3; TRAMP; LARD], [Tnfrsf25; Tnfrsf25; DR3; TR3; Wsl; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; Tnfrsf12] |
| Gene, Accession # | [DR3/Apo3], Gene ID: 85030, NCBI: AAH17526 |
| Catalog # | MBS840888 |
| Price | $150, $290 |
| Order / More Info | DR3 / Apo3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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