CYP11A1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CYP11A1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat. |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit IgG polyclonal antibody for Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) detection. Background: CYP11A1 (Cytochrome p450, family 11, subfamily A, polypeptide 1), commonly referred to as P450scc, is a mitochondrial enzyme associated with the conversion of cholesterol to pregnenolone. CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The CYP11A1 gene is mapped on 15q24.1. Expression of the CYP11A1 gene may play a role in skin physiology and pathology and that cutaneous proopiomelanocortin activity may be autoregulated by a feedback mechanism involving glucocorticoids synthesized locally. Using in vitro studies, CYP11A1 catalyzed the side-chain cleavage of 7-dehydrocholesterol to form 7-dehydropregnen |
| Immunogen | Immunogen: E Coli-derived human CYP11A1 recombinant protein (Position: M333-A418). Human CYP11A1 shares 89.5% amino acid (aa) sequence identity with both mouse and rat CYP11A1. |
| Other Names | [Cholesterol desmolase; CP11A; CYP 11A; CYP11A; Cyp11a; Cyp11a-1; CYP11A1; CYPXIA1; Cytochrome P450 11A1; Cytochrome P450(scc); P450SCC; P05108; Cholesterol side-chain cleavage enzyme, mitochondrial; cytochrome P450, family 11, subfamily A, polypeptide 1], [CYP11A1; CYP11A1; CYP11A; CYPXIA1; P450SCC; CYP11A] |
| Gene, Accession # | [CYP11A1], Gene ID: 1583, NCBI: NP_000772.2, UniProt: P05108 |
| Catalog # | MBS178442 |
| Price | $280 |
| Order / More Info | CYP11A1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. al Kandari, H., Katsumata, N., Alexander, S., Rasoul, M. A. Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46,XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum. J. Clin. Endocr. Metab. 91: 2821-2826, 2006.2. Chung, B.-C., Matteson, K. J., Voutilainen, R., Mohandas, T. K., Miller, W. L. Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Proc. Nat. Acad. Sci. 83: 8962-8966, 1986.3. Guryev, O., Carvalho, R. A., Usanov, S., Gilep, A., Estabrook, R. W. A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). Proc. Nat. Acad. Sci. 100: 14754-14759, 2003. |
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MYBIOSOURCE INC.
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