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Antigenic Specificity | DACH1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). |
Immunogen | Immunogen: Recombinant human Dachshund homolog 1 protein |
Other Names | [Dachshund homolog 1Dach1; DACH1; DACH] |
Gene, Accession # | [DACH1], Gene ID: 1602, NCBI: NP_004383.4, UniProt: Q9UI36 |
Catalog # | MBS7044494 |
Price | $160, $235 |
Order / More Info | DACH1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |