Hsp90 alpha/beta Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Hsp90 alpha/beta |
| Clone | [Hyb-K41220A] |
| Host Species | Mouse |
| Reactive Species | human, rat, S. cerevisiae, S. pombe. Limited or no reactivity to mouse or P.caudatum |
| Isotype | IgG2a |
| Format | ATTO 488 conjugate |
| Size | 0.1 mg |
| Concentration | 1mg/mL |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background Info: Detects 90kD proteins corresponding to the molecular mass of hsp90 alpha or beta. Scientific Background: HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms alpha and beta, which share 85% sequence amino acid homology. The two isoforms of Hsp90 are expressed in the cytosolic compartment (1). Despite the similarities, HSP90alpha exists predominantly as a homodimer while HSP90beta exists mainly as a monomer.(2) From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. (3-6) Furthermore, Hsp90 is highly conserved between species; having 60% and |
| Immunogen | n/a |
| Other Names | [Hsp86; Hsp89A; Hsp90AA1; Hsp90Alpha; HspC1; HSPCA; HspCAL3; Hsp84; Hsp90B; HspC2; HspCB; D6S182; FLJ26985], [HSP90AB1; HSP90AB1; HSP84; HSPC2; HSPCB; D6S182; HSP90B; HSP90B; HSPC2; HSPCB; HSP 90; HSP 84; HSP84] |
| Gene, Accession # | Gene ID: 3326, NCBI: NP_031381.2, UniProt: P08238 |
| Catalog # | MBS800630 |
| Price | $455 |
| Order / More Info | Hsp90 alpha/beta Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Nemoto, T. et al. (1997) J.Biol Chem. 272, 26179-26187. 2. Minami, Y, et al. (1991), J.Biol Chem. 266, 10099-10103. 3. Arlander SJH, et al. (2003) J Biol Chem 278, 52572-52577. 4. Pearl H, et al. (2001) Adv Protein Chem 59,157-186. 5. Neckers L, et al. (2002) Trends Mol Med 8:S55-S61. 6. Pratt W, Toft D. (2003) Exp Biol Med 228:111-133. 7. Pratt W, Toft D. (1997) Endocr Rev 18,306-360. 8. Pratt WB. (1998) Proc Soc Exptl Biol Med 217, 420-434. 9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91, 8324-8328. 10. Kishimoto J, et al. (2005). Cell Stress and Chaperones. 10 (4), 296-311. 1. Horvat, N. K., et al. (2014). A mutation in the catalytic loop of Hsp90 specifically impairs ATPase stimulation by Aha1p, but not Hch1p. J Mol Biol. pii: S0022-2836(14)00176-4. doi: 10.1016/j.jmb.2014.04.002 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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