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Antigenic Specificity | Human ICAM3 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein ICAM-3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting three members. It is a DC-SIGN ligand that is constitutively expressed on resting leukocytes, and is thus an important molecule for the first immune response. ICAM-3 comprises of five immunoglobulin-like domains, and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule, but also as a potent signalling molecule. ICAM-3 binds to LFA-1 on antigen-presenting cells (APC) stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex. However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling. It has been reported |
Immunogen | Immunogen: Recombinant Human CD50/ICAM-3 protein Buffer: 0.2 mum filtered solution in PBS with 5% trehalose |
Other Names | [intercellular adhesion molecule 3 isoform 3; Intercellular adhesion molecule 3; intercellular adhesion molecule 3; intercellular adhesion molecule 3; CDw50; ICAM-R; CD_antigen: CD50] |
Gene, Accession # | [ICAM3 ], Gene ID: 3385 |
Catalog # | MBS2543940 |
Price | $215, $330, $500 |
Order / More Info | Human ICAM3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |