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Antigenic Specificity | DDX42 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: DDX42 antibody detects endogenous levels of total DDX42. Function: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.Subunit Stru |
Immunogen | Immunogen: A synthesized peptide derived from human DDX42 Subcellular Location: Nucleus Tissue Specificity: Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets. Predicted Cross Reactivity: Pig, Bovine, Horse, Rabbit, Dog Similarity: Pig (100%), Bovine (100%), Horse (100%), Rabbit (100%), Dog (100%) |
Other Names | [ATP-dependent RNA helicase DDX42; DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; DEAD box polypeptide 42 protein; DEAD box protein 42; EC 3.6.1.-; FLJ43179; RHELP; RNA helicase-like protein; RNA helicase-related protein; RNAHP; SF3b DEAD-box protein; SF3b125; SF3b125 DEAD-box protein; Splicing factor 3B-associated 125 kDa protein] |
Gene, Accession # | [DDX42], Gene ID: 11325, NCBI: NP_031398.2, UniProt: Q86XP3 |
Catalog # | MBS9609576 |
Price | $240, $280 |
Order / More Info | DDX42 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |