SOX10 (Melanoma Marker) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SOX10 (Melanoma Marker) |
| Clone | [rSOX10/1074] |
| Host Species | Mouse |
| Reactive Species | human, mouse. |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) Formalin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is |
| Immunogen | Immunogen: Recombinant fragment of human SOX10 protein (around aa 115-269) Cellular Localization: Nuclear |
| Other Names | [DOM; PCWH; SOX10; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Waardenburg syndrome type 2E'(WS2E); WS4; Waardenburg syndrome type 4C (WS4C)'] |
| Gene, Accession # | [SOX10], Gene ID: 6663, NCBI: NP_008872.1, UniProt: P56693 |
| Catalog # | MBS4380228 |
| Price | $190, $340, $340 |
| Order / More Info | SOX10 (Melanoma Marker) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Mohamed A, et al. SOX10 Expression in malignant melanoma, carcinoma, and normal tissues. Appl Immunohistochem Mol Morphol. 2013; 21(6):506-10.? |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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