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Antigenic Specificity | NDFIP2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: NDFIP2 antibody detects endogenous levels of total NDFIP2. Function: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Endosome Membrane. Golgi Apparatus Membrane. Endosome > Multivesicular Body Membrane. Tissue Specificity: Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta. |
Other Names | [Ndfip2; NEDD4 family interacting protein 2; NEDD4 family-interacting protein 2; NEDD4 WW domain binding protein 5A; NEDD4 WW domain-binding protein 5A; NFIP2_HUMAN; Putative MAPK activating protein PM04/PM05/PM06/PM07; Putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF kappa B activating protein 413; Putative NF-kappa-B-activating protein 413] |
Gene, Accession # | [NDFIP2], Gene ID: 54602, NCBI: NP_061953.2, UniProt: Q9NV92 |
Catalog # | MBS9604110 |
Price | $240, $280 |
Order / More Info | NDFIP2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |