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Antigenic Specificity | IL10, 27-53 |
Clone | [530CT10.5.7] |
Host Species | Mouse |
Reactive Species | human (predicted reactivity: EBV, monkey) |
Isotype | IgM |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This IL10 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 27-53 amino acids from human IL10. The protein encoded by this gene is a cytokine producedprimarily by monocytes and to a lesser extent by lymphocytes. Thiscytokine has pleiotropic effects in immunoregulation andinflammation. It down-regulates the expression of Th1 cytokines,MHC class II Ags, and costimulatory molecules on macrophages. Italso enhances B cell survival, proliferation, and antibodyproduction. This cytokine can block NF-kappa B activity, and isinvolved in the regulation of the JAK-STAT signaling pathway.Knockout studies in mice suggested the function of this cytokine asan essential immunoregula |
Immunogen | n/a |
Other Names | [Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10] |
Gene, Accession # | [IL10], Gene ID: 3586, NCBI: NP_000563.1, UniProt: P22301 |
Catalog # | MBS9200076 |
Price | $370 |
Order / More Info | IL10, 27-53 Antibody from MYBIOSOURCE INC. |
Product Specific References | Huebinger, R.M., et al. J. Surg. Res. 164 (1), E141-E145 (2010) : Glocker, E.O., et al. Lancet 376 (9748), 1272 (2010) : Mosaad, Y.M., et al. Scand. J. Immunol. 72(4):358-364(2010) Kung, W.J., et al. Diabetes Technol. Ther. 12(10):809-813(2010) Santhosh, S., et al. Trop Gastroenterol 31(1):30-33(2010) |