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Antigenic Specificity | IL13 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: IL13 Antibody detects endogenous levels of total IL13. IL-13 is produced by T cells and is important in the TH2 response. IL-13 targets include B cells, eosinophils, fibroblasts, mast cells and macrophages (1-3). IL-13 binds specifically to IL-13Ralpha1 that complexes with IL-4Ralpha to form the Type II IL-4R. Jak1 and Tyk2 are activated and signal through Stat3 and Stat6 (6). IL-13Ralpha2 is a different gene product, lacks the intracellular domain, does not complex with IL-4Ralpha and does not signal (1, 6, 7). The extracellular domain of IL-13Ralpha2 is often elevated in diseased states. IL-13 plays key roles in airway hyperresponsiveness (AHR) of allergic asthma (1, 4, 5) and modulates resistance to parasitic organisms (1). |
Immunogen | Immunogen: Recombinant protein of human IL13 |
Other Names | [ALRH; BHR1; IL-13; MGC116786; MGC116788; MGC116789; P600] |
Gene, Accession # | [IL13], Gene ID: 3596, NCBI: NP_002179.2, UniProt: P35225 |
Catalog # | MBS8516283 |
Price | $290 |
Order / More Info | IL13 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |