Phospho-Rb (S788) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Rb (S788) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.45 |
| Applications | Dot Blot (DB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Rb Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S788 of human Rb. RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malign |
| Immunogen | n/a |
| Other Names | [Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110; RB1] |
| Gene, Accession # | [RB1], Gene ID: 5925, NCBI: NP_000312.2, UniProt: P06400 |
| Catalog # | MBS9214700 |
| Price | $165, $370 |
| Order / More Info | Phospho-Rb (S788) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Wagner, S., et al., Biochem. Pharmacol. 69(7):1059-1067 (2005). Roesch, A., et al., Mod. Pathol. 18(4):565-572 (2005). Lieman, J.H., et al., J. Biol. Chem. 280(11):10484-10490 (2005). Budde, A., et al., Oncogene 24(10):1802-1808 (2005). Zapata, E., et al., FEBS J. 272(6):1343-1353 (2005). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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