Edit |   |
---|---|
Antigenic Specificity | Phospho-INPP5D-Y1020 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding Y1020 of human INPP5D Immunogen Species: Human |
Other Names | [hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145] |
Gene, Accession # | [INPP5D-Y1020], Gene ID: 3635, NCBI: NP_001017915.1, UniProt: Q92835 |
Catalog # | MBS9135631 |
Price | $235, $350, $525 |
Order / More Info | Phospho-INPP5D-Y1020 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |