TNF-R1 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | TNF-R1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TNF-alpha is an important cytokine produced by numerous cell types including neutrophils, activated lymphoctyes, macrophages an NK cells. It plays a critical role in inflammatory responses and in apoptosis (1). TNF-alpha exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-alpha is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells (2). Antagonists to TNF-alpha have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders (3). The two receptors for TNF-alpha, TNF-R1 (55 kDa) and TNF-R2 (75 kDa) can mediate distinct cellular responses (4, 5). In most cases cytotoxicity elici |
| Immunogen | Immunogen: Recombinant protein of human TNF-R1. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [TNF R1; TNFRSF1A; TNFR1; CD120a; TNF R55; FPF], [TNFRSF1A; TNFRSF1A; FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNF-R1; TNF-RI; TNFR-I; TBPI] |
| Gene, Accession # | [TNF-R1], Gene ID: 7132, NCBI: NP_001056.1, UniProt: P19438 |
| Catalog # | MBS857072 |
| Price | $290 |
| Order / More Info | TNF-R1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Aggarwal, B.B. (2003) Nat Rev Immunol 3, 745-56. 2. Locksley, R.M. et al. (2001) Cell 104, 487-501. 3. Taylor, P.C. et al. (2004) Curr Opin Biotechnol 15, 557-63. 4. Tartaglia, L.A. et al. (1991) Proc Natl Acad Sci USA 88, 9292-6. 5. Peschon, J.J. et al. (1998) J Immunol 160, 943-52. 6. Tartaglia, L.A. et al. (1993) Cell 73, 213-6. 7. Rothe, J. et al. (1993) Nature 364, 798-802. 8. Chen, G. and Goeddel, D.V. (2002) Science 296, 1634-5. 9. Humbert, M. et al. (1994) Am J Respir Crit Care Med 149, 1681-5. 10. Schroder, J. et al. Infection 23, 143-8. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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