Human TIE-1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human TIE-1 |
| Clone | [IgG1; 6F12] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 0.05 mg |
| Concentration | n/a |
| Applications | ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The unconjugated monoclonal antibody will detect native human TIE-1 in ELISA experiments and on the surface of different human cell types. Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal pep |
| Immunogen | Immunogen: recombinant human soluble TIE-1. Conjugation: Biotin. Preparation: Monoclonal antibodies were produced with the help of BALB/c mice using recombinant human soluble extracellular domain of TIE-1. |
| Other Names | [human TIE-1-Biotin (#6F12); Tyrosine kinase with Ig and EGF homology domain-2], [TIE1; TIE1; TIE; JTK14; TIE] |
| Gene, Accession # | [TIE-1], Gene ID: 7075, NCBI: NP_005415, UniProt: P35590 |
| Catalog # | MBS690314 |
| Price | $345 |
| Order / More Info | Human TIE-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Reusch et al., Angiogenesis 4:123, 2001 2. Harris et al., Clin Cancer Res. 7 :1992, 2001 3. Partanen J and DJ Dumont (1999) Curr Top Microbiol Immunol 237:159. 4. Takakura N et al, (1998) Immunity 9:677. 5. Procopio W et al, (1999) J Biol Chem 274:30196. 6. Sato et al. (1993) PNAS 90:9355 7.Gale et al., (1999) Gen Dev 13:1055 8. Van Hoof et al, J Proteome Res 9:1610, 2010 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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