Phospho-Ser269 Aquaporin 2 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-Ser269 Aquaporin 2
Host SpeciesRabbit
Reactive Speciesrat
Formatpeptide affinity purified
Size0.1 mL
ApplicationsDB: Dot Blot, Western Blot (WB), Immunohistochemistry (IHC)
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DescriptionSpecificity: Specific for the ~29k AQP2 protein phosphorylated at Ser269. Also recognizes the glycosylated form of AQP2 at ~ 37k. Immunolabeling of the AQP2 band is blocked by preadsorption with the phospho-peptide used as antigen but not by the corresponding dephospho-peptide. Affinity purified rabbit polyclonal antibody
ImmunogenAntigen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser269 of rat aquaporin 2. Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser269 conjugated to KLH. Immunogen Species: Rat
Other Names[Voltage-dependent T-type calcium channel subunit alpha-1I,CACNA1I,oltage-gated calcium channel subunit alpha Cav3.3,Cav3.3], [Aqp2; Aqp2; AQP-2; aquaporin-2; AQP-2; AQP-CD]
Gene, Accession #[AQP2], Gene ID: 25386, NCBI: NP_037041.2, UniProt: P34080
Catalog #MBS502165
Order / More InfoPhospho-Ser269 Aquaporin 2 Antibody from MYBIOSOURCE INC.
Product Specific References• van Balkom BW, Savelkoul PJ, Markovich D, Hofman E, Nielsen S, van der Sluijs P, Deen PM (2002) The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin 2 water channel. J Biol Chem 277(44):41473-9.• Ford P, Rivarola V, Chara O, Blot-Chabaud M, Cluzeaud F, Farman M, Parisi M, Capurro C (2005) Volume regulation in cortical collecting duct cells: role of AQP2. Biol Cell 97(9):687-97• Hoffert JD, Nielsen J,, Yu MJ,, Pisitikun T,, Schleicher SM,, Nielsen Knepper MA (2007) Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Am J Physiol Renal Physiol 292: F691-F700.• Iolascon A, Aglio V, Tamma G, D'Appolito M, Addabbo F, Procino G, Simonetti MC, Montini G, Gesulado L, Debler EW, Suelto M, Valenti G (2007) Characterization of two novel missense mutations in AQP2 gene causing nephrogenic diabetes insipidus. Nephron Physiol. 105(3): p33-41.• Hoffert JD, Fenton RA, Moeller HB, Simons B, Tchapyjnikov D, McDill BW, Yu MJ, Pisitkun T, Chen F, Knepper MA. (2008) Vasopressin-stimulated increase in phosphorylation at serine 269 potentiates plasma membrane retention of aquaporin 2. J Biol Chem. 2008 Sep 5; 283(36):24617-27.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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