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Antigenic Specificity | KIT (Center) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This KIT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 336-367 amino acids from the Central region of human KIT. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 a |
Immunogen | n/a |
Other Names | [Mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; KIT; SCFR] |
Gene, Accession # | [KIT], Gene ID: 3815, NCBI: NP_000213.1, UniProt: P10721 |
Catalog # | MBS9211754 |
Price | $165, $370 |
Order / More Info | KIT (Center) Antibody from MYBIOSOURCE INC. |
Product Specific References | Yarden Y.,et al.EMBO J. 6:3341-3351(1987). Giebel L.B.,et al.Oncogene 7:2207-2217(1992). Andre C.,et al.Genomics 39:216-226(1997). Jin P.,et al.Arthritis Res. Ther. 10:R73-R73(2008). Neumann I.,et al.Pediatr. Blood Cancer 55:464-470(2010). |