Phospho-Thr53 NCC Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Thr53 NCC |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | guinea pig, hamster |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for endogenous levels of the ~160 kDa NCC protein phosphorylated at Thr53. Band of interest smearing likely due to glycosylation. Immunolabeling is completely eliminated by treatment with l-Ptase. The thiazide-sensitive sodium chloride cotransporter, NCC, is the major NaCl transport protein in the distal convoluted tubule (DCT) and plays an important role in maintaining blood pressure (Rosenbaek et al., 2014, Feng et al., 2015). Phosphorylation of NCC at Thr53, Thr58, and Ser71 is an essential mediator of NCC function (Rosenbaek et al., 2014). NCC is constitutively cycled to the plasma membrane, and upon stimulation, it can be phosphorylated to both increase NCC activity and decrease NCC endocytosis, together increasin |
| Immunogen | Immunogen Species: Mouse. Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr53 conjugated to KLH |
| Other Names | [solute carrier family 12 member 3 isoform 1; Solute carrier family 12 member 3; solute carrier family 12 member 3; solute carrier family 12, member 3; Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter], [SLC12A3] |
| Gene, Accession # | [NCC], Gene ID: 20497, NCBI: NP_001192240.1, UniProt: P59158 |
| Catalog # | MBS500073 |
| Price | $360 |
| Order / More Info | Phospho-Thr53 NCC Antibody from MYBIOSOURCE INC. |
| Product Specific References | Feng X, Zhang Y, Shao N, Wang Y, Zhuang Z, Wu P, Lee MJ, Liu Y, Wang X, Zhuang J, Delpire E, Gu D, Cai H. (2015) Aldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway. Am J Physiol Renal Physiol. 308(10):F1119-27Rosenbaek LL, Kortenoeven ML, Aroankins TS, Fenton RA. (2014) Phosphorylation decreases ubiquitylation of the thiazide-sensitive cotransporter NCC and subsequent clathrin-mediated endocytosis. J Biol Chem. 289(19):13347-61 |
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