Phospho-FGF Receptor 1 Tyr766 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-FGF Receptor 1 Tyr766 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosi |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding Tyr766 of human FGF Receptor 1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; bFGF-R-1; FLJ99988] |
| Gene, Accession # | [FGFR1], Gene ID: 2260, NCBI: NP_001167534.1, UniProt: P11362 |
| Catalog # | MBS8527422 |
| Price | $310 |
| Order / More Info | Phospho-FGF Receptor 1 Tyr766 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Powers, C.J. et al. (2000) Endocr Relat Cancer 7, 165-97. 2. Reilly, J.F. et al. (2000) J Biol Chem 275, 7771-8. 3. Mohammadi, M. et al. (1996) Mol Cell Biol 16, 977-89. 4. Mohammadi, M. et al. (1991) Mol Cell Biol 11, 5068-78. 5. Larsson, H. et al. (1999) J Biol Chem 274, 25726-34. 6. Partanen, J. et al. (1998) Genes Dev 12, 2332-44. |
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MYBIOSOURCE INC.
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