MerTK (Innate Immune Checkpoint) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | MerTK (Innate Immune Checkpoint) |
| Clone | [MERTK/3015] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG |
| Format | purified |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene enc |
| Immunogen | Immunogen: Recombinant human MERTK protein fragment (around aa 55-148) (exact sequence is proprietary) |
| Other Names | [cEyk; MER receptor tyrosine kinase; MERK; MERPEN; nmf12; Nyk; Proto-oncogene c-Mer; RP38; STK kinase] |
| Gene, Accession # | [MERTK], Gene ID: 10461, NCBI: NP_006334.2, UniProt: Q12866 |
| Catalog # | MBS4380783 |
| Price | $190, $340, $340 |
| Order / More Info | MerTK (Innate Immune Checkpoint) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Akalu Y.T., et al. TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy. Immunol Rev. 2017 Mar;276(1):165-177. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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