B-Raf (Ser-446), phospho-specific [Conserved Site: C-Raf (Ser-338)/A-Raf (Ser-299)] Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-B-Raf (Ser-446), phospho-specific [Conserved Site: C-Raf (Ser-338)/A-Raf (Ser-299)] antibody, protein, ELISA kits.
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| Antigenic Specificity | B-Raf (Ser-446), phospho-specific [Conserved Site: C-Raf (Ser-338)/A-Raf (Ser-299)] |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody was cross-adsorbed to phospho-B-Raf (Ser-579) peptide before affinity purification using phospho-B-Raf (Ser-446) peptide. The purified antibody detects a strong band at 95 kDa* and a weaker band at 105 kDa in western blots of human Jurkat or A431 cells treated with Calyculin A. The antibody also detects other phosphorylated proteins at 150 and 200 kDa in calyculin A treated cells. The Ras-Raf-MAP kinase signaling pathway is involved in control of cell proliferation and differentiation. The Raf kinase family includes A-Raf, BRaf, and C-Raf. Each family member has three highly conserved regions (CR1-3). The N-terminal CR1 contains the Ras-GTP-binding domain. The CR2 contains a negative regulatory serine residue (C-Raf (S259)/B-R |
| Immunogen | Immunogen: Phospho-B-Raf (Ser-446) synthetic peptide (coupled to KLH) corresponds to amino acids surrounding serine 446 in human B-Raf. This sequence is conserved in B-Rafs from many species, and has high homology to C-Raf (Ser-338) and A-Raf (Ser-299). |
| Other Names | [p94; v-Raf murine sarcoma viral oncogene homolog B1], [BRAF; BRAF; NS7; BRAF1; RAFB1; B-RAF1; FLJ95109; MGC126806; MGC138284; BRAF1; RAFB1] |
| Gene, Accession # | Gene ID: 673, NCBI: NP_004324.2, UniProt: P15056 |
| Catalog # | MBS472012 |
| Price | $385 |
| Order / More Info | B-Raf (Ser-446), phospho-specific [Conserved Site: C-Raf (Ser-338)/A-Raf (Ser-299)] Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Mason, C.S. et al. (1999) EMBOJ 18(8):2137.• Wilhelm, S.M. et al. (2004) Cancer Res 64:7099.• Karbowniczek, M. et al. (2006) J Biol Chem 281(35):25447.• Brummer, T. et al. (2006) Oncogene 25(47):6262. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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