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Antigenic Specificity | TIPRL |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of TIPRL protein. TIPRL (TOR Signaling Pathway Regulator) is a Protein Coding gene. May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C): TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C: pPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. |
Immunogen | Immunogen: Synthesized peptide derived from part region of human TIPRL protein |
Other Names | [Rabbit TIPRL; TIP41-like protein; Putative MAPK-activating protein PM10; Type 2A-interacting protein; TIP] |
Gene, Accession # | [TIPRL], Gene ID: 261726, NCBI: NP_001026970.1, UniProt: O75663 |
Catalog # | MBS9711219 |
Price | $130, $220, $325 |
Order / More Info | TIPRL Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |