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Antigenic Specificity | Human ERBB2 / HER2 |
Clone | [4E1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b,k |
Format | Protein A purified |
Size | 0.05 mg |
Concentration | 0.5 mg/ml |
Applications | Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Human ERBB2. A tyrosine kinase receptor in the EGF-receptor family. ErbB2 does not bind ligand on its own, but acts as an amplifier in heterodimers with ErbB1, (EGFR), ErbB3, or ErbB4. Amplification of the ErbB2 gene and overexpression of ErbB2 protein is associated with breast cancer (~25% of cases), and anti-ErbB2 therapeutics (e. g. Herceptin, an anti-ErbB2 monoclonal antibody) are sometimes effective in treating these cases. Overexpression of ErbB2 has also been indicated as a factor in prostate cancer. |
Immunogen | Immunogen Description: Recombinant protein |
Other Names | [ERBB2 / HER2 (clone 4E1) IHC-plus; ERBB2; C-erb B2/neu protein; CD340; HER2; Herstatin; MLN 19; HER-2; Neu; NGL; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; CD340 antigen; MLN19; p185erbB2; TKR1; Human ERBB2; HER2], [HER2] |
Gene, Accession # | [ERBB2], Gene ID: 2064, NCBI: NP_004439.2, UniProt: P04626 |
Catalog # | MBS246417 |
Price | $605 |
Order / More Info | Human ERBB2 / HER2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |