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Antigenic Specificity | Human LAP/ TGF beta 1 |
Clone | [6G14] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Neutr |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody was selected for its ability to detect human LAP TGF beta 1. TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic \'cysteine knot\'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling |
Immunogen | Preparation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of LAP-TGFb1. Antigen: Recombinant human LAP TGF beta 1 |
Other Names | [TGFB1; CED; LAP; DPD1; TGFB; TGFbeta], [TGFB1; TGFB1; CED; LAP; DPD1; TGFB; TGFbeta; TGFB; TGF-beta-1; LAP] |
Gene, Accession # | [LAP/ TGF beta 1], Gene ID: 7040, NCBI: NP_000651.3, UniProt: P01137 |
Catalog # | MBS690382 |
Price | $490 |
Order / More Info | Human LAP/ TGF beta 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |