GRB14 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityGRB14
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formatpeptide affinity purified
Size0.1 mL, 0.2 mL
Concentration1mg/ml
ApplicationsWestern Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
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DescriptionSpecificity: GRB14 antibody detects endogenous levels of total GRB14. Function: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.Subunit Structure: Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor (INSR), through the SH2 domain (By similarity). Interacts wit
ImmunogenImmunogen: A synthesized peptide Subcellular Location: Cytoplasm, Golgi Apparatus Membrane, Peripheral Membrane Protein, Endosome Membrane. Tissue Specificity: Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Xenopus (82%)
Other Names[GRB14 adapter protein; Grb14; GRB14_HUMAN; Growth factor receptor bound protein 14]
Gene, Accession #[GRB14], Gene ID: 2888, NCBI: NP_001290351.1, UniProt: Q14449
Catalog #MBS9605546
Price$240, $280
Order / More InfoGRB14 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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