PMS2 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | PMS2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | biotin conjugate |
| Size | 0.1 mg |
| Concentration | 0.65-0.69 ug/ul in antibody stabilization buffer |
| Applications | ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | BIOTIN-Conjugated Mismatch Repair Endonuclease PMS2 Antibody N-epitope. Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going t |
| Immunogen | Immunogen: Synthetic peptide taken within amino acid region 220-270 on human Mismatch Repair endonuclease PMS2 protein. |
| Other Names | [DNA mismatch repair gene homologue; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2; PMS2; PMS2CL; PMSL2; Postmeiotic segregation increased, S. cerevisiae, 2], [PMS2; PMS2; MLH4; PMSL2; HNPCC4; PMS2CL; PMSL2] |
| Gene, Accession # | [PMS2], Gene ID: 5395, NCBI: XP_011513729.1 |
| Catalog # | MBS544001 |
| Price | $495 |
| Order / More Info | PMS2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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