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Antigenic Specificity | SGO1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensin |
Immunogen | Immunogen: Recombinant Human Shugoshin 1 protein (260-439AA) Conjugation: Non-conjugated |
Other Names | [Shugoshin 1; Serologically defined breast cancer antigen NY-BR-85; Shugoshin-like 1; SGO1] |
Gene, Accession # | [SGO1], Gene ID: 151648, NCBI: NP_001012409.1, UniProt: Q5FBB7 |
Catalog # | MBS7052889 |
Price | $160, $235 |
Order / More Info | SGO1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |