Edit |   |
---|---|
Antigenic Specificity | PP2C alpha |
Clone | [p6c7] |
Host Species | Mouse |
Reactive Species | human, mouse |
Isotype | IgG2b, k |
Format | Protein G purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1mg/ml |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Protein phosphatase 2C (PP2Calpha) is a Mn2+ - or Mg 2+ -dependent protein serine/threonine phosphatase that inhibits the human stress-responsive p38 and JNk MAPk pathways and regulates cellular stress response in eukaryotes. The PPM (metal-dependent protein phosphatase) family of Ser/Thr protein phosphatases have recently been shown to down-regulate the stress response pathways in eukaryotes. Within the stress pathway, key signaling kinases, which are activated by protein phosphorylation, have been proposed as the in vivo substrates of PP2Calpha, the prototypical member of the PPM family. |
Immunogen | Immunogen: Recombinant human PP2Calpha (1-382aa) purified from E. coli |
Other Names | [Protein phosphatase 1A (formerly 2C) magnesium-dependent alpha isoform; PDP1; PDP; PPM2C; PP2C alpha; Protein phosphatase 2C; PDP 1; EC 3.1.3.43; Pyruvate dehydrogenase phosphatase catalytic subunit 1; PDPC 1; Pyruvate dehydrogenase acetyl-transferring-phosphatase 1; PPM1A; Protein phosphatase 1A (formerly 2C); ppm1a; FLJ42306; MGC9201; PP2CA; PP2Calpha; PP2C-alpha; protein phosphatase Mg2+/Mn2+ dependent 1A], [PPM1A; PPM1A; PP2CA; PP2Calpha; PP2C-ALPHA; PPPM1A; PP2C-alpha] |
Gene, Accession # | [PP2C alpha], Gene ID: 5494, NCBI: NP_066283, UniProt: P35813 |
Catalog # | MBS200003 |
Price | $240, $315 |
Order / More Info | PP2C alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | Lin X, et al., (2006) Cell. 125 (5): 915-928; Duan X, et al., (2006) J Biol Chem. 281 (48):36526-32 |