Edit |   |
Antigenic Specificity | ATRX/RAD54 (Alpha Thalassemia Mental Retardation) |
Clone | [ATRX/2900R] |
Host Species | Rabbit |
Reactive Species | human. |
Isotype | IgG |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistology (Formalin-Fixed) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 alpha to mediate chromosoma |
Immunogen | Immunogen: Recombinant full-length human ATRX protein Positive Control: Raji, HeLa or A431 Cells. Pancreas, Adrenal, Ovary, Kidney, Prostate or Stomach. |
Other Names | [Alpha thalassemia/mental retardation syndrome X linked homolog; ATP-dependent helicase ATRX; ATR2; ATRX; DNA-dependent ATPase and helicase; MRXHF1; RAD54; RAD54L; SFM1; SHS; Transcriptional regulator ATRX; X-linked helicase II; X-linked nuclear protein; XH2; XNP; Znf-HX] |
Gene, Accession # | [ATRX], Gene ID: 546, NCBI: NP_000480.3, UniProt: P46100 |
Catalog # | MBS4380661 |
Price | $190, $340, $340 |
Order / More Info | ATRX/RAD54 (Alpha Thalassemia Mental Retardation) Antibody from MYBIOSOURCE INC. |
Product Specific References | McDowell et al. 1999. Proc Natl Acad Sci U S A. 96(24):13983-8.; Lukashchuk et al. 2008. J Virol. 82(24):12543-54. |