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Antigenic Specificity | SSH3BP1 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for Abl interactor 1(ABI1) detection. Tested with WB, IHC-P in Human;Mouse;Rat. Background: SSH3BP1 is also known as ABI1. ABI1 is a human homolog of mouse Abl-interactor-1 (Abi1), mapped on 10p11.2. ABI1 participates in the transduction of signals from Ras to Rac by regulating Rac-specific guanine nucleotide exchange factor (GEF) activities. It dramatically promoted ABL1-mediated tyrosine phosphorylation of MENA, but not of other substrates. Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins. ABI1 plays a role in the leukemogenesis by translocating to MLL. |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human SSH3BP1 (151-175aa HGVKWLKAKHGNNQPARTGTLSRTN), identical to the related mouse and rat sequences. Ig Type: Rabbit IgG |
Other Names | [Abl interactor 1; Abelson interactor 1; ABI 1; Abi-1; ABI1; ABI1_HUMAN; Abl binding protein 4; Abl interactor 1; Abl interactor protein 1; Abl interactor protein 1 long; Abl-binding protein 4; AblBP4; Ablphilin 1; E3B1; Eps8 binding protein; Eps8 SH3 domain binding protein; Eps8 SH3 domain-binding protein; Eps8-binding protein; Hssh3bp1; Interactor protein AblBP4; NAP1; Nap1 binding protein; Nap1-binding protein; NAP1BP; Spectrin SH3 domain binding protein 1; Spectrin SH3 domain-binding protein 1; SSH3BP; abl-interactor 1], [ABI1; ABI1; E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1; SSH3BP1; Abi-1; AblBP4; Eps8-binding protein; Nap1BP] |
Gene, Accession # | [SSH3BP1], Gene ID: 10006, NCBI: NP_001012768.1, UniProt: Q8IZP0 |
Catalog # | MBS178018 |
Price | $315 |
Order / More Info | SSH3BP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Tani, K.; Sato, S.; Sukezane, T.; Kojima, H.; Hirose, H.; Hanafusa, H.; Shishido, T. : Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian Enabled (Mena) by c-Abl kinase. J. Biol. Chem. 278: 21685-21692, 2003. 2. Taki, T.; Shibuya, N.; Taniwaki, M.; Hanada, R.; Morishita, K.; Bessho, F.; Yanagisawa, M.; Hayashi, Y. : ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). Blood 92: 1125-1130, 1998. |