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Antigenic Specificity | MAPK7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 0.5 ug/ul in antibody stabilization buffer |
Applications | ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Overview: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the |
Immunogen | Immunogen: Synthetic peptide taken within amino acid region 700-750 on human Mitogen-activated protein kinase 7. Conjugation: Unconjugated |
Other Names | [Affinity Purified Mitogen-activated protein kinase 7; Big MAP kinase 1; BMK 1 kinase; ERK 5; Extracellular signal regulated kinase 5; MAP kinase 7; Mitogen-activated protein kinase 7; PRKM 7; PROTEIN KINASE, MITOGEN-ACTIVATED, 7] |
Gene, Accession # | [MAPK7], Gene ID: 5598, NCBI: NP_002740.2, UniProt: Q13164 |
Catalog # | MBS5400519 |
Price | $390 |
Order / More Info | MAPK7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |