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Antigenic Specificity | Phospho-Arrestin beta-1 (Tyr173) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, ratpredicted: porcine, zebrafish, bovine, horse, sheep, rabbit, dog, Xenopus |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Peptide ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-beta-Arrestin 1 (Tyr173) Antibody detects endogenous levels of beta-Arrestin 1 only when phosphorylated at Tyr173. Description: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the ad |
Immunogen | Immunogen: A synthesized peptide derived from human beta-Arrestin 1 around the phosphorylation site of Tyr173. |
Other Names | [ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1] |
Gene, Accession # | [ARB1], Gene ID: 408, NCBI: NP_004032.2, UniProt: P49407 |
Catalog # | MBS9610672 |
Price | $225, $280, $340 |
Order / More Info | Phospho-Arrestin beta-1 (Tyr173) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |