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Antigenic Specificity | CHEK2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA r |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human CHEK2 (NP 009125.1). |
Other Names | [CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425] |
Gene, Accession # | [CHEK2], Gene ID: 11200, NCBI: NP_001005735.1, UniProt: O96017 |
Catalog # | MBS8544831 |
Price | $280 |
Order / More Info | CHEK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |