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Antigenic Specificity | ULK2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neu |
Immunogen | Immunogen: Recombinant Human Serine/threonine-protein kinase ULK2 protein (211-276AA) |
Other Names | [Serine/threonine-protein kinase ULK2; Unc-51-like kinase 2; ULK2; KIAA0623] |
Gene, Accession # | [ULK2], Gene ID: 9706, NCBI: NP_001136082.1, UniProt: Q8IYT8 |
Catalog # | MBS7109332 |
Price | $160, $235 |
Order / More Info | ULK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |