Edit |   |
---|---|
Antigenic Specificity | AATF |
Clone | [3C7] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, k |
Format | Protein A purified |
Size | 0.05 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Human AATF. May function as a general inhibitor of the histone deacetylase HDAC1.Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2Fcomplexes, leading to activation of E2F target genes and cell cycleprogression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. |
Immunogen | Immunogen: AATF (AAH00591, 151 a.a. ~ 250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Conjugation: Unconjugated |
Other Names | [Rabbit (IgG) to Human AATF; AATF; CHE1; DED; Rb-binding protein Che-1; CHE-1; Protein AATF] |
Gene, Accession # | [AATF], Gene ID: 26574, NCBI: NP_036270.1, UniProt: Q9NY61 |
Catalog # | MBS2401124 |
Price | $605 |
Order / More Info | AATF Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |