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Antigenic Specificity | SYT1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: SYT1 antibody detects endogenous levels of total SYT1. Description: Synaptotagmin 1 (SYT1) is an integral membrane protein found in synaptic vesicles thought to play a role in vesicle trafficking and exocytosis (1). Individual SYT1 proteins are composed of an amino-terminal transmembrane region, a central linker region and a pair of carboxy-terminal C2 domains responsible for binding Ca2+ (2). The C2 domains appear to be functionally distinct, with the C2A domain responsible for regulating synaptic vesicle fusion in a calcium-dependent manner during exocytosis while the C2B domain allows for interaction between adjacent SYT1 proteins (3). Because synaptotagmin 1 binds calcium and is found in synaptic vesicles, this integral mem |
Immunogen | Immunogen: A synthesized peptide derived from human SYT1 Subcellular Location: Cytoplasmic Vesicle > Secretory Vesicle > Synaptic Vesicle Membrane. Cytoplasmic Vesicle > Secretory Vesicle > Chromaffin Granule Membrane. Cytoplasm. Synaptic vesicles and chromaffin granules. Tissue Specificity: Expressed in melanocytes (PubMed:23999003). |
Other Names | [DKFZp781D2042; FLJ42519; p65; SVP65; Synaptotagmin 2; Synaptotagmin I; Synaptotagmin II; Synaptotagmin-1; SYT; Syt1; SYT1_HUMAN; Syt2; SytI] |
Gene, Accession # | [SYT1], Gene ID: 6857, NCBI: NP_001129277.1, UniProt: P21579 |
Catalog # | MBS9606834 |
Price | $240, $280 |
Order / More Info | SYT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |