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Antigenic Specificity | MCU |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pat |
Immunogen | Immunogen: Recombinant Human Calcium uniporter protein, mitochondrial protein (155-233AA) |
Other Names | [Calcium uniporter protein, mitochondrial1 Publication; Coiled-coil domain-containing protein 109ACurated; MCU] |
Gene, Accession # | [MCU], Gene ID: 90550, NCBI: NP_001257608.1, UniProt: Q8NE86 |
Catalog # | MBS7104285 |
Price | $160, $235 |
Order / More Info | MCU Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |