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Antigenic Specificity | EBI3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35. Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of na ve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeuti |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 16 amino acid peptide from near the carboxy terminus of human EBI3. |
Other Names | [Epstein-Barr virus induced 3 precursor, interleukin-27 subunit beta, IL-27B] |
Gene, Accession # | [EBI3], Gene ID: 10148, NCBI: NP_005746 |
Catalog # | MBS9401567 |
Price | $320 |
Order / More Info | EBI3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |