SHP1 (C-terminal Region) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SHP1 (C-terminal Region) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, rat, mouse |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot, Immunocytochemistry, Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects a 68 kDa* protein in human A431 and Jurkat cells, and does not cross-react with SHP2. SHP1 (PTP1C, SH-PTP1, or HCP) is a protein-tyrosine phosphatase (PTP) involved in cell migration, cell proliferation, and immune cell function. This phosphatase contains two N-terminal SH2 domains and a C-terminal phosphatase domain. SHP1 associates with a variety of cytokine and growth factor receptors and regulates signal transduction through dephosphorylation of these receptors or their downstream effectors. Downstream of receptor activation, SHP1 regulates the transcriptional activity stimulated by JAK/Stat and MAPK pathways. SHP1 activity is regulated by both tyrosine and serine phosphorylation. Phosphorylation of Tyr-536 and Tyr- |
| Immunogen | Immunogen: Clone (M160) was generated from a recombinant protein containing amino acids in the C-terminal region of human SHP1. This sequence ishighly conserved in rat and mouse SHP1. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS470027 |
| Price | $325 |
| Order / More Info | SHP1 (C-terminal Region) Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Jones, M.L. et al. (2004) J. Biol. Chem. 279(39):40475.• Zhang, Z. et al. (2003) J. Biol. Chem. 278(7):4668.• Zhang, J. et al. (2000) Semin. Immunol. 12:361. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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