GAPDH (3B3) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | GAPDH (3B3) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: GAPDH (3B3) Mouse mAb. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the phosphorylation of glyceraldehyde-3-phosphate during glycolysis. Though differentially expressed from tissue to tissue, GAPDH is thought to be a constitutively expressed housekeeping protein. For this reason, GAPDH mRNA and protein levels are often measured as controls in experiments quantifying specific changes in expression of other targets. Recent work has elucidated roles for GAPDH in apoptosis, gene expression and nuclear transport. GAPDH may also play a role in neurodegenerative pathologies such as Huntington and Alzheimer's diseases. |
| Immunogen | Source Note: This monoclonal antibody is produced by immunizing animals with a synthetic peptide (KLH-coupled) corresponding to the carboxy terminus of human GAPDH. |
| Other Names | [Glyceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde-3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; 38 kDa BFA-dependent ADP-ribosylation substrate; BARS-38; Peptidyl-cysteine S-nitrosylase GAPDH (EC:2.6.99.-)], [LOC108351137; Gapdh; Gapd; GAPDH] |
| Gene, Accession # | [GAPDH], Gene ID: 108351137, NCBI: P04797.3, UniProt: P04797 |
| Catalog # | MBS435077 |
| Price | $215, $275, $370 |
| Order / More Info | GAPDH (3B3) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Barber, R.D. et al. 2005. GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues. Physiol. Genomics 21, 389-95.2.2. Hara, M.R. and Snyder, S.H. 2006. Nitric oxide-GAPDH-Siah: a novel cell death cascade. Cell Mol. Neurobiol. 26, 527-38.3. Zheng, L. et al. 2003. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell 114, 255-66.4. Bae, B.l. et al. 2006. Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH. Proc. Natl. Acad. Sci. USA 103f 3405-9.5. Wang, Q. et al. 2005. Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein. FASEB J. 19, 869-71. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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