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Antigenic Specificity | Human HLA DQ |
Clone | [NKI(SPV)L3] |
Host Species | Mouse (Balb/c) |
Reactive Species | human, porcine |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC), Immunohistochemistry (IHC) (frozen), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: NKI(SPV)L3 reacts with a monomorphic determinant on HLA-DQ (MHC class II). HLA-DQ (DQ) is a cell surface receptor type protein found on antigen presenting cells. DQ is an alphabeta heterodimer of the MHC Class II type. The alpha and beta chains are encoded by HLA-DQA1 and HLA-DQB1, respectively. These two loci are adjacent to each other on chromosome 6p21.3. Both the alpha-chain and beta-chain vary greatly. A person often produces two alpha-chain and two beta-chain variants and thus 4 DQ isoforms. The DQ loci are in close genetic linkage to HLA-DR but less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. DQ functions on antigen presenting cells, and is an antigen presenting molecule. Different DQ isoforms can bind to and prese |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS570226 |
Price | $415 |
Order / More Info | Human HLA DQ Antibody from MYBIOSOURCE INC. |
Product Specific References | Spits H., G. Keizer, J. Borst, C. Terhorst, A. Hekman and J.E. de Vries. Characterization of monoclonal antibodies anti cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines. Hybridoma 1983, 4: 423-437. Spits H., J. Borst, M. Giphart, J. Coligan, C. Terhorst and J.E. de Vries. HLA-DC antigens can serve as recognition elements for Human cytotoxic T lymphocytes. Eur. J. Immunol. 1984, 14: 299. A.A. te Velde, J.P.G. Klomp, B.A. Yard, J.E. de Vries, C.G. Figdor. Modulation of phenotypic and functional properties of Human peripheral blood monocytes by IL-4. J. of Immunol. 1988, 140: 1548-1554. |