Edit |   |
---|---|
Antigenic Specificity | PIST (C-term), 361-390 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This PIST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 361-390 amino acids from the C-terminal region of human PIST. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner. PIST, a PDZ domain-containing Golgi protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6. Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the acti |
Immunogen | n/a |
Other Names | [Golgi-associated PDZ and coiled-coil motif-containing protein; CFTR-associated ligand; Fused in glioblastoma; PDZ protein interacting specifically with TC10; PIST; GOPC; CAL; FIG] |
Gene, Accession # | [GOPC], Gene ID: 57120, NCBI: NP_001017408.1, UniProt: Q9HD26 |
Catalog # | MBS9206639 |
Price | $165, $370 |
Order / More Info | PIST (C-term), 361-390 Antibody from MYBIOSOURCE INC. |
Product Specific References | Li,X., Protein Sci. 15 (9), 2149-2158 (2006) Ito,H., Biochem. J. 397 (3), 389-398 (2006) Wente,W., J. Biol. Chem. 280 (37), 32419-32425 (2005) |