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Antigenic Specificity | CACYBP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat. |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit IgG polyclonal antibody for Calcyclin-binding protein (CACYBP) detection. Background: Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene. And this gene is mapped to 1q24-q25. The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. In addition, it probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CACYBP (7-47aa QKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQK), different from the related mouse sequence by five amino acids, and from the related rat sequence by six amino acids. |
Other Names | [CACYBP; Calcyclin-binding protein; GIG5; hCacyBP; PNAS107; S100A6-binding protein; S100A6BP; S100A6BP; SIP; SIAH Interacting Protein; Siah-interacting protein; Q9HB71 ; Calcyclin-binding protein; calcyclin binding protein], [CACYBP; CACYBP; SIP; GIG5; PNAS-107; S100A6BP; S100A6BP; SIP; CacyBP; hCacyBP] |
Gene, Accession # | [CACYBP], Gene ID: 27101, NCBI: NP_001007215.1, UniProt: Q9HB71 |
Catalog # | MBS178406 |
Price | $315 |
Order / More Info | CACYBP Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Matsuzawa, S., Reed, J. C. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.Molec. Cell 7: 915-926, 2001.2. Sun S, Ning X, Liu J, et al. (2007). Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma.. Biochem. Biophys. Res. Commun. 356 (4): 864-71. |