Edit |   |
---|---|
Antigenic Specificity | Human Tyrosine-protein kinase Lck |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | biotin conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gam |
Immunogen | Immunogen: Recombinant human Tyrosine-protein kinase Lck protein(1-539aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32014 / sc-13 / sc-28882 |
Other Names | [Leukocyte C-terminal Src kinase; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK; LCK], [LCK; LCK; LSK; YT16; IMD22; p56lck; pp58lck; LSK] |
Gene, Accession # | [Lck], Gene ID: 3932, NCBI: NP_001036236.1, UniProt: P06239 |
Catalog # | MBS1493284 |
Price | $160, $235 |
Order / More Info | Human Tyrosine-protein kinase Lck Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |