TDG, Human Antibody from NKMAX Co. Ltd.

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Antigenic SpecificityTDG, Human
CloneAT2F7
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1 kappa
FormatProtein A purified
Size50ul, 100ul
Concentration1mg/ml (determined by BCA assay)
ApplicationsELISA,WB,ICC/IF
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DescriptionG/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. Several bacterial proteins have strong sequence homology with this protein. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
ImmunogenRecombinant human TDG (1-410aa) purified from E. coli
Other NamesThymine-DNA glycosylase, G/T mismatch-specific thymine DNA glycosylase,
Gene, Accession #NCBI: AAH37557, UniProt: Q13569
Catalog #ATGA0251
Price$170, $290
Order / More InfoTDG, Human Antibody from NKMAX Co. Ltd.
Product Specific Referencesn/a
NKMAX Co. Ltd.
NKMAX Co. Ltd.
NKMAX Co. Ltd.
6F, SNUH Health Care Innovation Park
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do 13605 REPUBLIC OF KOREA
P: +82-31-8017-8114
F: +82-31-8017-8124

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