PP2C alpha/PPM1A, Human Antibody from NKMAX Co. Ltd.
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| Antigenic Specificity | PP2C alpha/PPM1A, Human |
| Clone | p6c7 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | Protein G purified |
| Size | 50ul, 100ul |
| Concentration | 1mg/ml (determined by BCA assay) |
| Applications | ELISA, WB, ICC/IF |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Protein phosphatase 2C (PP2Calpha) is a Mn2+ - or Mg 2+ -dependent protein serine/threonine phosphatase that inhibits the human stress-responsive p38 and JNk MAPk pathways and regulates cellular stress response in eukaryotes. The PPM (metal-dependent protein phosphatase) family of Ser/Thr protein phosphatases have recently been shown to down-regulate the stress response pathways in eukaryotes. Within the stress pathway, key signaling kinases, which are activated by protein phosphorylation, have been proposed as the in vivo substrates of PP2Calpha, the prototypical member of the PPM family. |
| Immunogen | Recombinant human PP2Calpha (1-382aa) purified from E. coli |
| Other Names | Pyruvate dehydrogenase phosphatase catalytic subunit 1, Pyruvate dehydrogenase acetyl-transferring-phosphatase 1, Protein phosphatase Mg2+/Mn2+dependent 1A, Protein phosphatase 2C, Protein phosphatase 1A (formerly 2C) magnesium-dependent alpha isoform, Protein phosphatase 1A (formerly 2C), PPM2C, PPM1A, PP2CA, PP2C alpha, PDPC 1, PDP 1, PDP, MGC9201, FLJ42306, EC 3.1.3.43 |
| Gene, Accession # | NCBI: NP_066283, UniProt: P35813 |
| Catalog # | APP0401 |
| Price | $170, $290 |
| Order / More Info | PP2C alpha/PPM1A, Human Antibody from NKMAX Co. Ltd. |
| Product Specific References | Kim JS, et al. The interaction of hepatitis B virus X protein and protein phosphatase type 2 Calpha and its effect on IL-6. (Biochem Biophys Res Commun. 2006){https://pubmed.ncbi.nlm.nih.gov/17055456/};;Budhiraja S, et al. Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression. Retrovirology. 2012 {https://pubmed.ncbi.nlm.nih.gov/22727189/};;Kim YG, et al. Role of protein phosphatase magnesium-dependent 1A and anti-protein phosphatase magnesium-dependent 1A autoantibodies in ankylosing spondylitis. (Arthritis Rheumatol. 2014){https://pubmed.ncbi.nlm.nih.gov/24980965/};;Tabony AM, et al. Protein phosphatase 2C-alpha knockdown reduces angiotensin II-mediated skeletal muscle wasting via restoration of mitochondrial recycling and function. (Skelet Muscle. 2014){https://pubmed.ncbi.nlm.nih.gov/25625009/};;Chen W, et al. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. (Nat Cell Biol. 2015){https://pubmed.ncbi.nlm.nih.gov/25751141/};;Pereira JM, et al. Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. (Cell Rep. 2018){https://pubmed.ncbi.nlm.nih.gov/29694890/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
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