SHANK2 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | SHANK2 |
| Clone | N23b/6 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1mg/mL |
| Applications | Immunohistochemistry, IF Microscopy, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-SHANK2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with SHANK2 from human, mouse, and rat based on 100% homology with the immunizing sequence. No cross-reactivity against Shank1 or Shank3. Cross-reactivity with Shank2 from other sources has not been determined. Scaffolds research. Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the shank post synaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease. |
| Immunogen | SHANK2 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to an internal region of (SH3/PDZ domains) of rat Shank2 (SH3 and multiple ankyrin repeat domains protein 2. |
| Other Names | SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, GKAP/SAPAP-interacting protein, Proline-rich synapse-associated protein 1, ProSAP1, SPANK-3 |
| Gene, Accession # | Shank2, Gene ID: 171093, NCBI: NP_958738.1, UniProt: Q9QX74 |
| Catalog # | 200-301-G44 |
| Price | $485 |
| Order / More Info | SHANK2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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