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Antigenic Specificity | IL-1 Receptor Type II |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, primate |
Isotype | n/a |
Format | serum |
Size | 100 µL |
Concentration | 85 mg/mL |
Applications | ELISA, Immunoprecipitation, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antiserum is directed against the extracellular domain of the human IL-1R type II, but precipitates the intact receptor expressed on human cells. In general, this antibody also detects primate IL-1RII. The antibody does not recognize human IL-1, IL-1Ra or IL-1R type I. In ELISA formats and other immunoreactive assays, this antibody will detect the extracellular domain of the IL-1R type II (also called soluble IL-1R type II) found in human body fluids, particularly in the circulation, urine and supernatants of cells and synovial fluid. Interleukin-1 Receptor Type 2 (IL-1RII) is a non-signaling receptor for IL1A, IL1B and IL1RN and reduces IL1B activities. It serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. It also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
Immunogen | This whole rabbit serum was prepared by repeated immunizations with recombinant human IL-1R type II. |
Other Names | IL1RB antibody, Interleukin 1 receptor type II precursor antibody, MGC47725 antibody, p68 antibody, Type II interleukin 1 receptor beta antibody, Antigen CDw121b antibody, rabbit anti-interleukin-1 Receptor Type II Antibody |
Gene, Accession # | IL1R2, Gene ID: 7850, NCBI: P27930.1, UniProt: P27930 |
Catalog # | 109-401-305-0100 |
Price | $475 |
Order / More Info | IL-1 Receptor Type II Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |