RANKL Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | RANKL |
| Clone | 12A668 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 0.5 mg/mL |
| Applications | Immunohistochemistry, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-RANKL Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with RANKL from Human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-RANKL from other sources has not been determined. Anti-RANKL TRANCE CD254 detects mouse RANKL TRANCE CD254. RANKL, or Trance, is a member of tumor necrosis factor family. Trance (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and DCs. Trance binds to RANK on DCs and upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in DC survival. Trance is also important in T- and B-cell maturation. As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. Trance deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis. Anti-RANKL TRANCE CD254 is ideal for investigators involved in apoptosis research. |
| Immunogen | RANKL Antibody was produced in mice by repeated immunizations with a bacterially expressed fusion protein corresponding to the n-terminus RANKL protein. |
| Other Names | CD254,hRANKL2, ODF, OPGL, OPTB2, RANKL, sOdf, TRANCE,Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine |
| Gene, Accession # | TNFSF11, Gene ID: 8600, NCBI: NP_003692.1, UniProt: O14788 |
| Catalog # | 200-301-I07 |
| Price | $549 |
| Order / More Info | RANKL Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.